Immunoadsorption Immuno-Adsopak® columns are used for elimination of autoantibodies, all classes of immunoglobulins, and immune complexes from the blood plasma of patients during therapeutic extracorporeal procedure.
Apheresis procedure with Immuno-Adsopak® columns is indicated for autoimmune diseases and conditions associated with the production of autoantibodies:
- dilated cardiomyopathy
- Eaton–Lambert syndrome
- Guillian–Barre syndrome
- multiple sclerosis
- systemic lupus erythematosus
- chronic inflammatory demyelinating polyneuropathy
- thrombotic thrombocytopenic purpura
- severe Rh incompatibility during pregnancy
- coagulation factor inhibitors
- antiphospholipid syndrome
- rheumatoid arthritis
- Goodpasture syndrome
- preparation for organ transplantation and transplant rejection
Theoretical background for application
The procedure of Ig apheresis is not highly specific for pathogenic autoantibodies. During the procedure all immunoglobulins class G and M are removed, including the immune complexes.
The peculiarity of autoimmune processes is that they usually affect a wide range of antibodies with only few of them known. Furthermore, there are numerous autoimmune diseases of unkown etiology. Therefore, to effectively influence on the pathological process, the ability of eliminating all immunoglobulins and immune complexes is the most effective. Unlike the autoantibodies and immune complexes, the concentratin of normal immunoglobulins quickly replenishes after the procedure.
The columns are released in plastic cases of 150 and 300 mL in volume.
The active ingredient of columns is a sotbent containing synthetic ligand selectively binding human IgG, immobilized on an inert polysaccharide matrix.
Plasmoperfusion, Ig apheresis
Type of plasmaseparator — membrane / centrifugal
Multiple-use — 5 procedures
Shelf-Life — 2 years
- Model Sorbent volume Binding capacity
- Immuno-Adsopak® 150 150 mL 4,0-5,0 gr immunoglobulin
- Immuno-Adsopak® 300 300 mL 8,0-10,0 gr immunoglobulin